| Título: | High-performance liquid chromatography of water-soluble vitamins. Part 3. Simultaneous determination of vitamins B1, B2, B6, B12 and C, nicotinamide and folic acid in capsule preparations by ion-pair reversed-phase high-performance liquid chromatography |
| Autores: | AMIN, MORIN ; REUSCH, JOACHIM |
| Tipo de documento: | texto impreso |
| ISBN/ISSN/DL: | 39000 |
| Nota general: | ISBN: |
| Langues: | Inglés |
| Clasificación: | |
| Resumen: | An ion-pair reversed-phase high-performance liquid chromatographic (HPLC) method for the separation and simultaneous determination of thiamine HCl (vitamin B1), riboflavin (vitamin B2), nicotinamide, pyridoxine HCl (vitamin B6), cyanocobalamin (vitamin B12), ascorbic acid (vitamin C) and folic acid in capsule preparations is described. The above seven active substances were extracted from the preparations within 5 min using an electronically controlled extraction apparatus. Ion-pair reversed-phase HPLC was carried out on LiChrosorb RP-18 using methanol-water-concentrated phosphoric acid-octanesulphonic acid as the eluent. All seven active ingredients were separated in less than 4 min. The detection limits were 1-2 ng for all vitamins |
| Nota de contenido: | En: Analyst. -- 112 (7) : 989-991 (1987) |
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