|
Título:
|
Determination of folic acid in tablets by microemulsion electrokinetic chromatography
|
|
Autores:
|
MS AURORA-PRADO, Autor ;
CA SILVA, Autor ;
MF TAVARES, Autor ;
KEVIN D. ALTRIA, Autor
|
|
Tipo de documento:
|
texto impreso
|
|
ISBN/ISSN/DL:
|
68228
|
|
Nota general:
|
En: J Chromatogr A. 2004 Oct 8;1051(1-2):291-6.
|
|
Langues:
|
Inglés
|
|
Clasificación:
|
EMULSIONES
MICROSCOPIA ELECTRONICA
|
|
Resumen:
|
A microemulsion electrokinetic chromatography (MEEKC) method has been developed and validated for the determination of folic acid, a water-soluble vitamin, in a commercial tablet formulation. The analysis was performed using a microemulsion containing 0.5% (w/w) ethyl acetate, 1.2% (w/w) butan-1-ol, 0.6% (w/w) sodium dodecyl sulfate, 15% (v/v) 2-propanol and 82.7% (w/w) 10 mmol L(-1) sodium tetraborate aqueous buffer at pH 9.2. Direct UV detection at 214nm led to an adequate sensitivity without interference from sample excipients. For quantitative purposes, niacin was used as internal standard. Acceptable precision (
|
