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Resumen:
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Convergent advances in photonics and chemistry are enabling many promising optically based technologies for biomedical imaging and phototherapy.1 Successful clinical application is dependent upon the continuing development of bright, nanometerscale, long-wavelength visible and near-infrared (NIR) emissive organic materials.1a,2 For deep-tissue fluorescence-based imaging, we have developed NIR-emissive polymersomes3ssynthetic vesicles which stably incorporate numerous multiporphyrin-based NIR fluorophores4 within their thick lamellar membranes. Polymersomes (50 nm to 50 ím diameter polymer vesicles) have been tailored to possess a rich diversity in material properties, including tunable in vivo circulation times, specific adhesiveness, environmental responsiveness, and biodegradability.5 Here, we demonstrate that incorporation of an extended family of multi[(porphinato)zinc(II)] (PZn)-based supermolecular fluorophores gives rise to a rich photophysical diversity in emissive polymersomes, enabling emission energy modulation over a broad spectral domain. Moreover, controlling polymer-to-fluorophore noncovalent interactions finely tunes the bulk photophysical properties of these soft, supramolecular, optical materials.
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